The Palestinian Organization for Development the COVID-19 Mitigation Project in the Gaza Strip, in partnership with the Palestinian Organization for Development and with funding from the United States Agency for International Development (USAID), from February 2022 to January 15, 2023. The project aimed to achieve two main objectives: first, to accelerate widespread and equitable access to safe and effective COVID-19 vaccines; and second, to reduce COVID-19-related morbidity and mortality, limit transmission, and strengthen health systems for prevention, detection, and response to pandemic threats. A significant number of residents from the Central Governorate benefited from the project’s activities. Approximately 2,313 individuals participated in health awareness sessions and received personal hygiene kits. Additionally, around 377 families were visited at home, where awareness sessions were conducted and hygiene kits were distributed. The project also hosted a Caritas medical clinic on a weekly basis, providing free screening and treatment for respiratory and influenza illnesses, as well as monitoring and medical care for COVID-19 patients. Furthermore, around 20 awareness messages were posted on the Authority’s social media platforms to promote COVID-19 awareness and encourage vaccination.